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A Novel Method for the Synthesis of α,β-Unsaturated Amides Mediated by Samarium Diiodide

✍ Scribed by Zhu, Chun-Lan; Wang, Xia-Xia


Book ID
126838340
Publisher
Chinese Electronic Periodical Services
Year
2005
Tongue
English
Weight
41 KB
Volume
52
Category
Article
ISSN
0009-4536

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Synthesis of (E)-α,β-Unsaturated Amides
✍ José M. Concellón; Juan A. Pérez-Andrés; Humberto Rodríguez-Solla 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 1 views

Stereoselective b-elimination of 2-chloro-3-hydroxyamides 1 is achieved by using samarium diiodide to yield a,b-unsaturated amides 2, in which the C C bond is di-tri-, or tetrasubstituted. The starting compounds 1 are easily prepared by reaction of the corresponding lithium enolates of a-chloroamide