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A novel fluorescent tag for labelling of some antisense oligonucleotides

✍ Scribed by K.K. Dubey; R.K. Singh; K. Misra

Book ID
117410197
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
535 KB
Volume
31
Category
Article
ISSN
0197-0186

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## Abstract The synthesis of 4(5)‐(bromomethyl)fluorescein, which can be used as its 3β€²,6′‐dibenzoyl derivative 7 for the labelling of nucleosides is described. Pyrimidine nucleosides such as 3′‐and/or5′‐protected 2′‐deoxyuridine and thymidine are labelled by 7 at N^3^ of the heterocyclic base. The