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A novel, double-asymmetric aldol approach to the synthesis of a 1β-methyl carbapenem antibiotic precursor

✍ Scribed by Fumiyuki Shirai; Takeshi Nakai

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 245 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)82373-4

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✦ Synopsis

A novel synthetic approach to the 1 B-methyl carbapenem key precursor is described -whichinvolvesthe chelation-controlled double-asymmetric aldol reaction as the key step.

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