## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
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A novel deletion in exon 15 of the adenomatous polyposis coli gene in an Italian kindred
โ Scribed by Alessandro Cama; Raffaele Palmirotta; Diana Esposito; Maria Cristina Curia; Annalisa Ranieri; Ferdinando Ficari; Rosa Valanzano; Pasquale Battista; Luigi Frati; Francesco Tonelli; Renato Mariani-Costantini
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 399 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1059-7794
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## BACKGROUND. Medulloblastomas can occur sporadically or may be associated with hereditary tumor syndromes including familial adenomatous polyposis (FAP) and nevoid basal cell carcinoma syndrome (NBCCS). ## METHODS. The authors performed a retrospective analysis for allelic deletion of the adeno