Identification of a novel single base insertion in the adenomatous polyposis coli gene
β Scribed by Maritha J. Kotze; Johanna J. Grobbelaar; Micheal V. Madden
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 181 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1059-7794
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Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o
## Background: The authors examined somatic mutations of the adenomatous polyposis coli (apc) gene in 84 human aberrant crypt foci (acf) to determine whether apc gene mutations were involved in the histologic progression of acf. ## Methods: Mutation cluster regions of the apc gene were subjected
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