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A Novel Class of 4′-Aza Analogues of 2′,3′-Dideoxynucleosides as Potential Anti-HIV Drugs

✍ Scribed by Leggio, Antonella; Liguori, Angelo; Procopio, Antonio; Siciliano, Carlo; Sindona, Giovanni


Book ID
120202267
Publisher
Taylor and Francis Group
Year
1997
Tongue
English
Weight
212 KB
Volume
16
Category
Article
ISSN
0732-8311

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ChemInform Abstract: A Novel Class of 4′
✍ A. LEGGIO; A. LIGUORI; A. PROCOPIO; C. SICILIANO; G. SINDONA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

A Novel Class of 4'-Aza Analogues of 2',3'-Dideoxynucleosides as Potential anti-HIV Drugs. -The novel isoxazoline nucleoside (VI) (no yield given) is prepared by 1,3-dipolar cycloaddition of a nitrone to vinyladenine (III).

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New synthesis approaches that have led to a series of novel aza analogues of the 2-substituted-2,3-dihydro-1,4-benzodioxin core, bearing versatile bromomethyl group on the non aromatic oxygenated ring, are described. According to their structures these novel scaffolds can be useful intermediates for