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Synthesis of 3′-substituted-2′,3′-dideoxynucleoside analogs as potential anti-aids drugs

✍ Scribed by Michel Maillard; Abdesslem Faraj; François Frappier; Jean-Claude Florent; David S. Grierson; Claude Monneret

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
243 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

3 '-Aaino-3' -deoxythy.nidine 2 was prepared in six steps and in 67% overall yield from rhymidine. Five derivatives of 9 and compound 17 were tested -for their anti-HIV activity.

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A Novel Class of 4'-Aza Analogues of 2',3'-Dideoxynucleosides as Potential anti-HIV Drugs. -The novel isoxazoline nucleoside (VI) (no yield given) is prepared by 1,3-dipolar cycloaddition of a nitrone to vinyladenine (III).