## Abstract **Summary:** This study investigated two new biodegradable polymers as gene controlledβreleased coatings for gene transfer. Poly(ethylene glycol)β__co__βpoly(D,Lβlactic acid) (PELA) and poly(ethylene glycol)β__co__βpoly(lactic acid)β__co__βpoly(glycolic acid) random copolymer (PELGA) we
A Novel Biodegradable Gene Carrier Based on Polyphosphoester
β Scribed by Wang, Jun; Mao, Hai-Quan; Leong, Kam W.
- Book ID
- 120318930
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 102 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0002-7863
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The aim of research was to develop and optimize delivery systems for plasmid DNA (pDNA) based on biodegradable polymers, in particular, poly(ester amine)s (PEAs), suitable for non-viral gene therapy. Poly(ester amine)s were successfully synthesized by Michael addition reaction between polycaprolacto
## Abstract ## Background Polyethylenimine (PEI) vectors are widely used in gene delivery because of their high transfection efficiency owing to a unique proton sponge effect. An increase in molecular weight increases transfection efficiency, but simultaneously results in increased toxicity. There