A novel design of a biodegradable carrier for drug delivery was established by constructing a supramolecular assembly of drugs and polymer backbones without any covalent bonds. A biodegradable polyrotaxane was synthesized in which a-cyclodextrins (a-CDs) as drug carriers were threaded onto poly(ethy
A Biodegradable Polymeric Carrier Based on PEG for Drug Delivery
✍ Scribed by Mero, A.; Schiavon, O.; Pasut, G.; Veronese, F. M.; Emilitri, E.; Ferruti, P.
- Book ID
- 115466902
- Publisher
- SAGE Publications
- Year
- 2009
- Tongue
- English
- Weight
- 288 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0883-9115
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## Abstract In this work, a biodegradable poly(ethylene glycol)‐poly(ε‐caprolactone)‐poly (ethylene glycol) (PEG‐PCL‐PEG, PECE) triblock copolymer was successfully synthesized. The aqueous solution of such PECE copolymer displayed special sol–gel–sol transition as temperature increase, which is a f
## Abstract A series of amphiphilic poly(L‐leucine)‐__block__‐poly(ethylene glycol)‐__block__‐poly(L‐leucine) (PLL‐PEG‐PLL) hybrid triblock copolymers have been synthesized. All the blocks in this system have good biocompatibility and low toxicity. The PLL‐PEG‐PLL copolymers could self‐assemble int