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Synthesis of a biodegradable polymeric supramolecular assembly for drug delivery

โœ Scribed by Tooru Ooya; Hideharu Mori; Minoru Terano; Nobuhiko Yui

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
268 KB
Volume
16
Category
Article
ISSN
1022-1336

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โœฆ Synopsis

A novel design of a biodegradable carrier for drug delivery was established by constructing a supramolecular assembly of drugs and polymer backbones without any covalent bonds. A biodegradable polyrotaxane was synthesized in which a-cyclodextrins (a-CDs) as drug carriers were threaded onto poly(ethy1ene glycol) chains which then were capped at each chain end by L-phenylalanine via peptide linkages. The release of a-CDs was observed only when the terminal peptide linkages were degraded.

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## Abstract Gadolinium diethylenetriamine pentaacetic acid (Gdโ€DTPA) was encapsulated into biodegradable, bioadhesive polymeric microparticles to enable noninvasive monitoring of their local intravesical delivery with MRI. The microparticles were characterized by contrast agent encapsulation and re