A novel antiproliferative agent, phenylpyridineylbutenol, isolated from Streptomyces sp.
β Scribed by Choonshik Shin; Haeyoung Lim; Sangik Moon; Seunghyun Kim; Yeonjoong Yong; Bum-Joon Kim; Chul-Hoon Lee; Yoongho Lim
- Book ID
- 108074125
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 131 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0960-894X
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## Abstract From the endophytic strain __Streptomyces__ sp. CS of __Maytenus hookeri__, five novel type III polyketides, compounds **1**β**5**, were isolated. Their structures were elucidated by spectroscopic analyses including 1Dβ and 2DβNMR experiments, and by HRβESIβMS.
Cytoxazone [(4R,5R)-(-)-5-hydroxymethyl-4-(4-methoxyphen-employing the Sharpless asymmetric dihydroxylation as the key reaction in 26% overall yield (7 steps). yl)-2-oxazolidinone, 1], a new immunosuppressant, was synthesized by starting from p-methoxycinnamyl alcohol (2) In 1998 Osada and co-worke