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A Novel Antiproliferative Agent, Phenylpyridineylbutenol, Isolated from Streptomyces sp.

โœ Scribed by Choonshik Shin; Haeyoung Lim; Sangik Moon; Seunghyun Kim; Yeonjoong Yong; Bum-Joon Kim; Chul-Hoon Lee; Yoongho Lim


Publisher
John Wiley and Sons
Year
2007
Weight
12 KB
Volume
38
Category
Article
ISSN
0931-7597

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Cytoxazone [(4R,5R)-(-)-5-hydroxymethyl-4-(4-methoxyphen-employing the Sharpless asymmetric dihydroxylation as the key reaction in 26% overall yield (7 steps). yl)-2-oxazolidinone, 1], a new immunosuppressant, was synthesized by starting from p-methoxycinnamyl alcohol (2) In 1998 Osada and co-worke