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A Novel 1,5-Benzoheteroazepine Synthesis via a One-Pot Coupling−Isomerization−Cyclocondensation Sequence §

✍ Scribed by Braun, Roland U.; Zeitler, Kirsten; Müller, Thomas J. J.


Book ID
124101931
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
61 KB
Volume
2
Category
Article
ISSN
1523-7060

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An efficient and general one-pot procedure for the synthesis of pyrazoles from acid chlorides, terminal alkynes and hydrazines was described via a coupling and cyclocondensation sequence. Acid chlorides coupled with terminal alkynes to give a,b-unsaturated ynones, and in situ converted into pyrazole