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One-Pot Three-Component Synthesis of 3,5-Disubstituted Isoxazoles by a Coupling–Cyclocondensation Sequence

✍ Scribed by Liu, Hai-Ling; Geng, Zhu-Feng; Zhang, Si-Yu; Han, Jie


Book ID
121656236
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2014
Tongue
English
Weight
322 KB
Volume
89
Category
Article
ISSN
0385-5414

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One-pot three-component synthesis of pyr
✍ Hai-Ling Liu; Huan-Feng Jiang; Min Zhang; Wen-Juan Yao; Qiu-Hua Zhu; Zhou Tang 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 138 KB

An efficient and general one-pot procedure for the synthesis of pyrazoles from acid chlorides, terminal alkynes and hydrazines was described via a coupling and cyclocondensation sequence. Acid chlorides coupled with terminal alkynes to give a,b-unsaturated ynones, and in situ converted into pyrazole