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One-pot three-component synthesis of pyrazoles through a tandem coupling-cyclocondensation sequence

✍ Scribed by Hai-Ling Liu; Huan-Feng Jiang; Min Zhang; Wen-Juan Yao; Qiu-Hua Zhu; Zhou Tang

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
138 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient and general one-pot procedure for the synthesis of pyrazoles from acid chlorides, terminal alkynes and hydrazines was described via a coupling and cyclocondensation sequence. Acid chlorides coupled with terminal alkynes to give a,b-unsaturated ynones, and in situ converted into pyrazoles by the cycloaddition of hydrazines. The desired pyrazoles were obtained with 15-85% isolated yields.

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