A note on the mechanism of UV mutagenesis in Escherichia coli
β Scribed by Bryn A. Bridges
- Book ID
- 118952154
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- English
- Weight
- 429 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0027-5107
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Uvm mutants of Escherichia coli K12 selected for defective UV reversion induction have previously been reported to differ considerably from the UV-reversion-less recA and lexA mutants with regard to survival or mutagenic response to UV, X-rays and alkylating agents. In the present study, the phenoty
Using a nonselective method, we have estimated the proportion of untargeted mutations in the lad gene of E. coli by transferring either irradiated or unirradiated F' pro lac plasmids from an excision deficient donor to an excision deficient pro lac deleted recipient that had been irradiated and allo
Selection for defective reversion induction, after UV treatment of E. coli K 12, yielded uvm mutants. These mutants exhibited highly reduced or no UV mutability for all loci tested although they were moderately and normally mutable by X-rays and EMS, respectively. Uvm mutations confer only a slight