𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A Notable Cleavage: Winding up with β -amyloid

✍ Scribed by Kenneth S. Kosik

Book ID
123641865
Publisher
National Academy of Sciences
Year
1999
Tongue
English
Weight
760 KB
Volume
96
Category
Article
ISSN
0027-8424

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Amyloid precursor protein mutation E682K
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation
✍ Lujia Zhou; Nathalie Brouwers; Iryna Benilova; Annelies Vandersteen; Marc Mercke 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

BACE1 cleaves the amyloid precursor protein (APP) at the b-cleavage site (Met 671 -Asp 672 ) to initiate the generation of amyloid peptide Ab. BACE1 is also known to cleave APP at a much less well-characterized b 0 -cleavage site (Tyr 681 -Glu 682 ). We describe here the identification of a novel AP