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A nonlinear three-compartment model for the administration of 2′,3′-dideoxycytidine by using red blood cells as bioreactors

✍ Scribed by F. Solimano; G.I. Bischi; M. Bianchi; L. Rossi; M. Magnani

Book ID
108393311
Publisher
Springer
Year
1990
Tongue
English
Weight
493 KB
Volume
52
Category
Article
ISSN
1522-9602

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An optimal time control problem for the
An optimal time control problem for the administration of 2′,3′-dideoxycytidine by using red blood cells as bioreactors
✍ E. Beretta; F. Solimano 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 693 KB

The problem of optimal dosage is studied for the administration of ddCyd using erythrocytes as carriers and bioreactors. The volume of erythrocytes and the initial amount of drug to be loaded have to be determined in such a way that the duration of the therapeutic effect is maximized without exceedi