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A new twist for the tumour suppressor hamartin

✍ Scribed by Gutkind, J. Silvio; Fukuhara, Shigetomo

Book ID: 109769462
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 101 KB
Volume: 2
Category: Article
ISSN: 1465-7392
DOI: 10.1038/35010506

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Two molecular pathways leading to cancer are known. Common-type cancers arise from the 'tumour suppressor' pathway, characterized by gross chromosomal changes and allelic losses (LOH) in an average of 25 per cent or more of randomly chosen chromosomal loci. The 'mutator pathway' has been recognized