The first total synthesis of (+)-perhydrohistrionicotoxin (I), a useful neurotoxin, 1 was recently reported from these Laboratories. 2,3 We now describe a new, efficient and stereocontrolled route which leads to (t)-perhydrohistrionicotoxin
β¦ LIBER β¦
A new synthetic route to cyclic polyarsines
β Scribed by Gupta, Virendra K.; Krannich, Larry K.; Watkins, Charles L.
- Book ID
- 126463336
- Publisher
- American Chemical Society
- Year
- 1987
- Tongue
- English
- Weight
- 423 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0020-1669
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## Abstract Starting from ethyl 2βcyclohexenβ1βcarboxylate (**3**) the total synthesis of the perhydrohistrionicotoxin intermediate **23** was achieved in 25% overallβyield. The two key steps involve a positionally specific addition of HOBr to the oximeβolefin **7** and the alkylation of bromooxime