A new synthetic route to 2- and 4-methoxyestradiols by nucleophilic substitution
β Scribed by Shu-hua Chen; Guan-rong Luo; Xu-sen Wu; Min Chen; Hua-ming Zhao
- Book ID
- 116065118
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 903 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0039-128X
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## Abstract A new synthetic route to 4βsubstitutedβ2,2β²βbithiophenes has been developed utilizing 4βbromoβ2,2β²βbithiophene (1). Formation of the bithienyllithium adduct __via__ halogenβmetal exchange was found to be problematic and resulted in complex mixtures of products. The Grignard reagent of 1
Abstracf; The synthesis of some 5.. 6-, and 7.halogenouiazoIopyridines is described. and theii reactioos with nucleophiies. The formation of 7.7'-biuiazolopyridincs provides a new synthesis of 22'4ipyrklincs. Q 1997