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A new synthetic route to pyrogallolestrogen dimethyl ethers by nucleophilic substitution of 2,4-dibromoestrogens

✍ Scribed by Xu-hua Zheng; Wen-long Wang; Zhi-zheng Zhong; Zhen-bon Xu; Hua-ming Zhao


Book ID
118978896
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
254 KB
Volume
40
Category
Article
ISSN
0039-128X

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## Abstract The reaction of 3‐chloro‐6‐phenyl‐1,2,4‐triazine **1a** with carbon nucleophiles **2aο£Ώd** bearing a cyano substituent at a carbanionic center has been studied. In all reactions the formation of the corresponding 3‐aminopyridazines **3aο£Ώd** takes place via ANRORC mechanism involving addi