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A New Synthesis Of Coenzymically Active Water-Soluble Macromolecular Nad And Nadp Derivatives

✍ Scribed by Bückmann, Andreas F.

Book ID
120355703
Publisher
Informa UK (Taylor & Francis)
Year
1987
Tongue
English
Weight
889 KB
Volume
1
Category
Article
ISSN
0886-4454

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Alkylation of Adenine, Adenosine, and NAD+ with 1,3-Propanesultone. Synthesis of N6-(3-sulfonatopropyl)-NAD+, a new NAD+ derivative with substantial coenzyme activity
✍ Gianconno Carrea; Gianluca Ottolina; Sergio Riva; Bruno Danieli; Giordano Lesma; 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 German ⚖ 727 KB

The reactivity of 1,3-propanesultone with adenine, adenosine, and NAD+ was studied in order to prepare N6-(3-sulfonatopropy1)-NAD+ (3b), a new NAD' derivative substituted at the purine moiety with substantial coenzyme activity for several dehydrogenases. The regiochemistry of the alkylation at the p