Deprotonation of alanine ester imines with KO'Bu in DMSO or DMF and alkylation of the formed enolates with several 2-fluoroalkyl halogenides 2 and subsequent hydrolysis of the imino and the ester groups are presented as an efficient three-step sequence for the synthesis of racemic title compounds 5.
✦ LIBER ✦
A new synthesis of 3-fluoro phnylalanine esters
✍ Scribed by Tamsir N. Wade; François Gaymard; Roger Guedj
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 125 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
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