A new strategy for the synthesis of spiro[4,5]decanes: A formal total synthesis of acorone

✍ Scribed by P.John Biju; G.S.R.Subba Rao

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 145 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00114-8

✦ Synopsis

A new strategy for the construction of spiro [4,5]decanes is described and involves a bridgehead substitution of a methoxyl group in 6 by a methyl group, followed by an oxidative cleavage resulting in a stereogenic spirocentre which culminated in the formal synthesis of acorone.