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A New Stereocontrolled Approach to a Key Intermediate in the Synthesis of (2S,3R)-Capreomycidine

✍ Scribed by Martinková, Miroslava; Gonda, Jozef; Džoganová, Martina


Book ID
115446620
Publisher
UOCHB
Year
2006
Tongue
English
Weight
124 KB
Volume
71
Category
Article
ISSN
0010-0765

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Stereocontrolled Synthesis of (2R,3S)-2-
✍ Dan J. Darley; Thorsten Selmer; William Clegg; Ross W. Harrington; Wolfgang Buck 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 141 KB

## Abstract 2‐Methylisocitrate (=3‐hydroxybutane‐1,2,3‐tricarboxylic acid) is an intermediate in the oxidation of propanoate to pyruvate (=2‐oxopropanoate) __via__ the methylcitrate cycle in both bacteria and fungi (__Scheme 1__). Stereocontrolled syntheses of (2__R__,3__S__)‐ and (2__S__,3__R__)‐2

Stereocontrolled route to a key intermed
✍ E.J. Corey; Mark G. Bock 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 210 KB

We have undertaken a synthesis of this substance as part of a broader program in the area of biologically active macrocyclic natural products. One attractive approach to the synthesis of maytansine involves the introduction of chiraltty at carbons 3, 4, 5, 10, and 9 after formation of the macro ring