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A stereocontrolled synthesis of the key intermediate of (+)-thienamycin from (R)-(−)-3-hydroxybutyric acid esters

✍ Scribed by Minoru Hatanaka; Hajime Nitta


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
266 KB
Volume
28
Category
Article
ISSN
0040-4039

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## Abstract 2‐Methylisocitrate (=3‐hydroxybutane‐1,2,3‐tricarboxylic acid) is an intermediate in the oxidation of propanoate to pyruvate (=2‐oxopropanoate) __via__ the methylcitrate cycle in both bacteria and fungi (__Scheme 1__). Stereocontrolled syntheses of (2__R__,3__S__)‐ and (2__S__,3__R__)‐2