A stereocontrolled synthesis of the key intermediate of (+)-thienamycin from (R)-(−)-3-hydroxybutyric acid esters
✍ Scribed by Minoru Hatanaka; Hajime Nitta
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 266 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The enantioselective hydrogenation of (E)-2-(4-methoxy-3-(3-methoxypropoxy)-benzylidene)-3-methylbutanoic acid (1) to (R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutanoic acid (2)-a key intermediate in the synthesis of the pharmacologically important renin inhibitor Aliskiren-is described.
## Abstract 2‐Methylisocitrate (=3‐hydroxybutane‐1,2,3‐tricarboxylic acid) is an intermediate in the oxidation of propanoate to pyruvate (=2‐oxopropanoate) __via__ the methylcitrate cycle in both bacteria and fungi (__Scheme 1__). Stereocontrolled syntheses of (2__R__,3__S__)‐ and (2__S__,3__R__)‐2