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A New Route to the Synthesis of 2-Amino-6-(methoxycarbonyl)amino-4-(tetrahydropyridyl)pyrimidine 1-Oxide

✍ Scribed by Jean-Claude Muller; Henri Ramuz; Hans-Peter Wagner

Publisher
John Wiley and Sons
Year
1983
Tongue
German
Weight
248 KB
Volume
66
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A new approach to 2‐amino‐6‐(methoxycarbonyl)amino‐4‐(1,2,3,6‐tetrahydro‐1‐pyridyl)pyrimidine 1‐oxide (3) is described. Methyl [1‐ethoxy‐2‐(ethoxycarbonyl)‐ethylidene]carbamate (5) reacted with guanidine to the pyrimidinecarbamate 6, which was successively transformed into methyl 2‐amino‐6‐(p‐tolyslulfonyl)oxy‐4‐pyrimidinecarbamate (8). Oxidation of 8 led to the corresponding pyrimidine N‐oxide 9, a useful starting material to 3.

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