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A Facile Route to the Synthesis of Novel 2-Amino-1,4,5,6-tetrahydropyrimidines from Baylis—Hillman Products of Acrylonitrile.

✍ Scribed by Richa Pathak; Amrendra K. Roy; Sanjay Batra


Publisher
John Wiley and Sons
Year
2005
Weight
22 KB
Volume
36
Category
Article
ISSN
0931-7597

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✍ Samia M. Sayed; Mohamed A. Raslan; Mohamed A. Khalil; Kamal M. Dawood 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 2 views

The novel and versatile cyanomethyl 2amino-4-methylthiazolyl ketone (5) was prepared by treatment of bromomethyl 2-amino-4-methyl thiazolyl ketone (4) with potassium cyanide. Reaction of 5 with heterocyclic diazonium salts 6a,b and 10 afforded the corresponding hydrazones 7a,b and 11, respectively.