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A new route to homochiral trans-disubstituted cyclopentanes

✍ Scribed by Samuel G. Levine; Mary Pat Bonner

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 220 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)80503-7

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✦ Synopsis

Asymmetric epoxidation of cyano-substituted allylic alcohols gave epoxides of high optical purity.

Subsequent base-promoted cyclization produced diastereomerically pure cyclopentane derivatives in moderate yield.

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