A new route to cyclic amines by anionic cyclization
β Scribed by Iain Coldham; Richard Hufton
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 179 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Rhodium-catalysed reactions of aminoalkenes with H2/CO give cyclic amines with a range of medium and large ring sizes in yields up to 85%. High regioselectivity for non-branched products can be obtained when BIPHEPHOS is used as a ligand in the hydroformylation reaction.
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A Direct Route to Medium and Large Cyclic Amines from Aminoalkenes. -Rhodium-catalyzed hydroformylation of N-substituted alkenylamines in the presence of the bulky BIPHEPHOS ligand leads to formation of medium and large cyclic amines, e.g. (III), (V), and (VII). Important side reactions include hyd