A New Platform for Designing Ligands for Asymmetric Induction in Allylic Alkylations
โ Scribed by Prof. Barry M. Trost; Bernhard Breit; Stefan Peukert; Jorge Zambrano; Joseph W. Ziller
- Book ID
- 101558071
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 331 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Chiral imidazolidine ligands have been synthesized from N,N%-dialkylated cyclohexanediamine derivatives and they were found to act as effective ligands in the palladium-catalyzed asymmetric allylic substitution. The excellent levels of enantiomeric excess up to 98% were obtained in high yield.
The branched, chiral products 1 are formed preferentially in the allylic alkylations in Equation (1) when the Pd catalyst contains the P,N ligand L\* or derivatives thereof. The ligands are readily synthesized from commercially available precursors.