A New Multicomponent Reaction Catalyzed by a Lewis Acid Catalyst: Convenient Synthesis of Polyfunctional Tetrahydropyrimidines
✍ Scribed by Min Zhang; Huan-Feng Jiang
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 180 KB
- Volume
- 2009
- Category
- Article
- ISSN
- 1434-193X
No coin nor oath required. For personal study only.
✦ Synopsis
Lewis acids
📜 SIMILAR VOLUMES
## Abstract An efficient, one‐pot, multicomponent reaction of aldehydes **1**, __p__‐methoxyaniline (**2a**), and 2‐vinylindoles **3** was developed. This approach provides a practical approach to synthetically and biologically significant tetrahydro‐γ‐carboline and tetrahydroquinoline derivatives
## Abstract Iodine was explored as an efficient catalyst for the synthesis of tetrahydropyrimidines **4** and pyrrolidines **5** by a multicomponent reaction of dialkyl acetylenedicarboxylates (=dialkyl but‐2‐ynedioates) **1**, amines **2**, and HCHO **3** at room temperature (__Scheme__). When the