A Convenient Synthesis of Coumarins by Palladium(II)-Catalyzed Reaction of Phenols with Propiolic Acids.
โ Scribed by Masashi Kotani; Kiyomi Yamamoto; Juzo Oyamada; Yuzo Fujiwara; Tsugio Kitamura
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 29 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract magnified image Palladiumโcatalyzed coupling reaction was found effective for rapid access to pharmacologically interesting 3,4โdiarylisoxazoles derivatives as selective COXโ2 inhibitors. Thus, the coupling reaction between 5โalkylthioโ3โarylโ4โiodoisoxazoles and arylboronic acids affo