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A convenient synthesis of 5-alkylthio-3,4-diarylisoxazoles by palladium-catalyzed coupling reactions

✍ Scribed by Roozbeh Eskandari; Latifeh Navidpour; Mohsen Amini; Abbas Shafiee; Hamed Shafaroodi; Abbas Shafiee

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
309 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Palladium‐catalyzed coupling reaction was found effective for rapid access to pharmacologically interesting 3,4‐diarylisoxazoles derivatives as selective COX‐2 inhibitors. Thus, the coupling reaction between 5‐alkylthio‐3‐aryl‐4‐iodoisoxazoles and arylboronic acids afforded the target 5‐alkylthio‐3,4‐diarylisoxazoles in good yields.

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