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A new gold standard for the detection of Chlamydia trachomatis?

✍ Scribed by Gilles R.G. Monif

Publisher: Hindawi Publishing Corporation
Year: 1998
Tongue: English
Weight: 40 KB
Volume: 6
Category: Article
ISSN: 1064-7449
DOI: 10.1002/(sici)1098-0997(1998)6:1<44::aid-idog9>3.0.co;2-7

No coin nor oath required. For personal study only.

✦ Synopsis

C ell-culture techniques have long been consid- ered the ''gold standard'' for the detection of Chlamydia trachomatis. The major advantage of cellculture isolation is the specificity, which approaches 100%; however, even in experienced laboratories, its sensitivity is only 70-80%. 1-3 Its primary use has been in detecting symptomatic carriers in low-prevalence populations. Nonculture objective methods, such as enzyme immunoassay, DNA probe, polymerase chain reaction (PCR), and ligase chain reaction (LCR), have been used primarily in symptomatic or high-risk, highprevalence asymptomatic populations (Table 1).

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