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A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

✍ Scribed by Weisz, Boaz; Giehl, Klaudia; Gana-Weisz, Mali; Egozi, Yaakov; Ben-Baruch, Gilad; Marciano, Daniela; Gierschik, Peter; Kloog, Yoel


Book ID
110062038
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
250 KB
Volume
18
Category
Article
ISSN
0950-9232

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Growth inhibition of ras-dependent tumor
✍ Yaakov Egozi; Boaz Weisz; Mali Gana-Weisz; Gilad Ben-Baruch; Yoel Kloog πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 181 KB πŸ‘ 1 views

A lipophilic farnesyl moiety attached to the carboxyl terminal cysteine of ras proteins structurally supports their membrane anchorage, required for ras-dependent growth-factor signaling and for transforming activity of ras oncoproteins. It has been shown that inhibition of ras farnesylation can blo