Growth inhibition of ras-dependent tumor
β
Yaakov Egozi; Boaz Weisz; Mali Gana-Weisz; Gilad Ben-Baruch; Yoel Kloog
π
Article
π
1999
π
John Wiley and Sons
π
French
β 181 KB
π 1 views
A lipophilic farnesyl moiety attached to the carboxyl terminal cysteine of ras proteins structurally supports their membrane anchorage, required for ras-dependent growth-factor signaling and for transforming activity of ras oncoproteins. It has been shown that inhibition of ras farnesylation can blo