## Abstract The epithelial cell adhesion molecule (EpβCAM) is expressed on the surface of most human carcinomas, including ovarian, breast, lung, prostate and colorectal carcinoma. EpβCAM was shown to be a valid target for monoclonal antibodyβbased therapies. We have investigated whether an EpβCAMβ
β¦ LIBER β¦
A new format of bispecific antibody: highly efficient heterodimerization, expression and tumor cell lysis
β Scribed by Zhigang Xie; Ning Guo; Ming Yu; Meiru Hu; Beifen Shen
- Book ID
- 113716906
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 345 KB
- Volume
- 296
- Category
- Article
- ISSN
- 0022-1759
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## Abstract Trifunctional bispecific antibodies can efficiently mediate tumor cell killing by redirecting T cells and immune accessory cells to the tumor cell. Here, we describe the new trifunctional antibody, Bi20 (FBTA05, antiβCD20 Γ antiβCD3), that connects B cells and T cells __via__ its variab