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Potentiation of lysis of leukaemia cells by a bispecific antibody to CD33 and CD16 (FcγRIII) expressed by human natural killer (NK) cells

✍ Scribed by Lucia M. R. Silla; Jian Chen; Rui-kun Zhong; Theresa L. Whiteside; Edward D. Ball


Book ID
114714468
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
729 KB
Volume
89
Category
Article
ISSN
0007-1048

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In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell lines HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternber