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A new entry to the stereocontrolled synthesis of CD rings of Taxol

✍ Scribed by J.S. Yadav; Pradip K. Sasmal

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
189 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Stereocontrolled synthesis of the highly functionalized CD subunit of Taxol utilizing Diels-Alder reaction, Baeyer-Villiger oxidation of bridged keto system, stereodirected hydroboration using thexylborane and stereoselective Sharpless allylic hydroxylation as the key steps is described.

πŸ“œ SIMILAR VOLUMES

New synthesis of a taxol A-ring system.
New synthesis of a taxol A-ring system.
✍ Magnus Polla; TorbjΓΆrn Frejd πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 French βš– 552 KB

Absfhzct. The optically active tax01 A-ring unit 3 was synthesized in 11 steps from 2-isopropyl-2-propenol. The stereogenic centers were introduced via the asymmeuic glyoxylateene reaction and the Sharpless asymmetric epoxidation reaction. The total synthesis of tax01 (1) and analogous compounds ha