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A new, elegant route to a key intermediate for the synthesis of 9(0)-methanoprostacyclin

โœ Scribed by Barco, Achille; Benetti, Simonetta; Pollini, Gian Piero; Baraldi, Pier Giovanni; Gandolfi, Carmelo

Book ID
126800027
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
396 KB
Volume
45
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES

Stereocontrolled route to a key intermed
Stereocontrolled route to a key intermediate for the synthesis of maytansine
โœ E.J. Corey; Mark G. Bock ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 210 KB

We have undertaken a synthesis of this substance as part of a broader program in the area of biologically active macrocyclic natural products. One attractive approach to the synthesis of maytansine involves the introduction of chiraltty at carbons 3, 4, 5, 10, and 9 after formation of the macro ring

A simple route to a key intermediate for
A simple route to a key intermediate for the synthesis of 11-desoxyprostaglandins
โœ E.J. Corey; T. Ravindranathan ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 148 KB

received in U.K. for publication 8 Iiovember 1971) 11-Desoxyproetaglandlna are of considerable current interest as possible substrates for mlcrobiological hydroxylatlon at C(ll) (pro&mold numbering) and elsewhere, as poaslble antagonlsta of the prostagl&dlns in the E and F series, and as hypotenslve

A highly efficient route to a key interm
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โœ E.J. Corey; Paul A. Grieco ๐Ÿ“‚ Article ๐Ÿ“… 1972 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 139 KB

The iodo lactone I, which has been used as a key intermediate for the synthesis of the six natural primary prostaglandins, is readily available by a synthetic process in which the average yield per step is 95% (l-4). Although the A prostaglandins can be derived from the primary E prostaglandins by d