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A new class of models for computing receptor-ligand binding affinities

✍ Scribed by Michael K. Gilson; James A. Given; Martha S. Head


Book ID
114355989
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
521 KB
Volume
4
Category
Article
ISSN
1074-5521

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The synthesis, receptor binding, and preliminary structural characterisation of trishomocubanes of types pentacyclo [5.4.0.02'6.03'lΒ°.05'9]undecylamines and 4-azahexacyclo[5.4.1.0E'6.03'lΒ°.05'9.08'll]dodecanes are described. These ligands demonstrated high selectivity and affinity for the sigma bind