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A new base substitution in the 5′ regulatory region of the humanAγ globin gene is linked with the βsgene

✍ Scribed by George P. Patrinos,Aphrodite Loutradi-Anagnostou,Manoussos N. Papadakis


Book ID
118291704
Publisher
Springer
Year
1996
Tongue
English
Weight
91 KB
Volume
97
Category
Article
ISSN
0340-6717

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The ATTTT repeat polymorphism located approximately 1,400 base pairs (bp) upstream from the beta-globin structural gene was analyzed by denaturing gradient gel electrophoresis (DGGE) of RNA:DNA duplexes. A study of 81 unrelated Japanese from Hiroshima revealed a sequence heteromorphism in this site.