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A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins

✍ Scribed by Malin A. Andersson; Robert Epple; Valery V. Fokin; K. Barry Sharpless


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
87 KB
Volume
114
Category
Article
ISSN
0044-8249

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Osmium-Catalyzed Dihydroxylation of Olef
✍ Philippe Dupau; Robert Epple; Allenβ€…A. Thomas; Valeryβ€…V. Fokin; K.β€…Barry Sharple πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 179 KB πŸ‘ 1 views

A screen of over 500 diversely functionalized additives in osmium-catalyzed dihydroxylation has uncovered that electron-deficient olefins are converted into the corresponding diols much more efficiently when the pH of the reaction medium is maintained on the acidic side. Further studies have identif