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ChemInform Abstract: A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins.

✍ Scribed by Malin A. Andersson; Robert Epple; Valery V. Fokin; K. Barry Sharpless


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
33
Category
Article
ISSN
0931-7597

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A screen of over 500 diversely functionalized additives in osmium-catalyzed dihydroxylation has uncovered that electron-deficient olefins are converted into the corresponding diols much more efficiently when the pH of the reaction medium is maintained on the acidic side. Further studies have identif