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A new approach for the synthesis of O-glycopeptides through a combination of solid-phase glycosylation and fluorous tagging chemistry (SHGPFT)

✍ Scribed by Liu, Bo; Zhang, Fa; Zhang, Yan; Liu, Gang


Book ID
127187290
Publisher
Royal Society of Chemistry
Year
2014
Tongue
English
Weight
403 KB
Volume
12
Category
Article
ISSN
1477-0520

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with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the target