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A mutational analysis of the active site of human type II inosine 5′-monophosphate dehydrogenase

✍ Scribed by Olga Futer; Michael D. Sintchak; Paul R. Caron; Elmar Nimmesgern; Maureen T. DeCenzo; David J. Livingston; Scott A. Raybuck


Book ID
114149095
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
470 KB
Volume
1594
Category
Article
ISSN
0167-4838

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The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools. IMPDH exists as 2 isoforms, one of which is induced in tumor cells, type II and thus