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Selective Inhibition of Human Molt-4 Leukemia Type II Inosine 5‘-Monophosphate Dehydrogenase by the 1,5-Diazabicyclo[3.1.0]hexane-2,4-diones †

✍ Scribed by Barnes, Betsy J.; Eakin, Ann E.; Izydore, Robert A.; Hall, Iris H.


Book ID
120488353
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
287 KB
Volume
39
Category
Article
ISSN
0006-2960

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✍ Betsy J. Barnes; Robert A. Izydore; Ann E. Eakin; Iris H. Hall 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 122 KB

The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools. IMPDH exists as 2 isoforms, one of which is induced in tumor cells, type II and thus