Mechanism of action of the antitumor age
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Betsy J. Barnes; Robert A. Izydore; Ann E. Eakin; Iris H. Hall
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Article
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2001
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John Wiley and Sons
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French
⚖ 122 KB
The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools. IMPDH exists as 2 isoforms, one of which is induced in tumor cells, type II and thus