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Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death

โœ Scribed by Betsy J Barnes; Ann E Eakin; Robert A Izydore; Iris H Hall


Book ID
113992682
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
326 KB
Volume
62
Category
Article
ISSN
0006-2952

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โœ Betsy J. Barnes; Robert A. Izydore; Ann E. Eakin; Iris H. Hall ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 122 KB

The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools. IMPDH exists as 2 isoforms, one of which is induced in tumor cells, type II and thus