Kinetic Mechanism of Human Inosine 5‘-Monophosphate Dehydrogenase Type II: Random Addition of Substrates and Ordered Release of Products †

Mechanism of action of the antitumor age

Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: Potent inhibitors of human type II inosine 5′-monophosphate dehydrogenase

✍ Betsy J. Barnes; Robert A. Izydore; Ann E. Eakin; Iris H. Hall 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 122 KB

The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools. IMPDH exists as 2 isoforms, one of which is induced in tumor cells, type II and thus